We estimated VE for any influenza-associated illness overall and by season and by prespecified age groups. Close mobile search navigation Article Navigation. I think, especially in this population, in older adults, the influenza vaccine is the best way to prevent influenza, which caused 80, deaths in the United States last year. Issue Section:. Sign In or Create an Account.
Research has shown that patients taking. Studies have shown that patients who take statins may have a reduced immune response to the influenza vaccine compared with patients who.
Statins Do Not Affect Influenza Risk Following Vaccination The Cardiology Advisor
Statins, in addition to their lipid-lowering properties, may also have anti-inflammatory effects. This observation has led to concern that patients.
Also, the investigators did not account for body mass index, smoking status, diet, or socioeconomic status in statin users and nonusers, which may have affected the findings.
Supplementary materials are available at Clinical Infectious Diseases online. Influenza vaccine effectiveness in the season: protection against each circulating virus and the effect of prior vaccination on estimates.
Sample size may also have been inadequate to detect smaller effects of statins on VE. Internal Medicine.
Effect of Statin Use on Influenza Vaccine Effectiveness
The authors analyzed data from participants within the US Influenza Vaccine Effectiveness Network during 6 influenza seasons — If 2 types of statins were listed, the statin with the earliest prescription date was used.
Recent studies suggest that statin use may reduce influenza vaccine effectiveness (VE), but laboratory-confirmed influenza was. Reassuring” results from a study of individuals show that statin use does not affect the effectiveness of the influenza vaccine. We compared influenza VE in statin users and nonusers aged ≥45 years enrolled in the US Vaccine Effectiveness Network study over 6.
Disclosures: Some authors declared financial conflicts of interest with this study.
Video: Statins and influenza vaccine Researchers study how powerful medications affect influenza vaccine
Compared with non-statin users, statin users had an adjusted relative risk RR for influenza-related doctor visits of 1. We found that for all influenza types and subtypes, including influenza A H3N2there was no significant difference between statin users and nonusers, nor did we observe an effect of statin use on the odds of influenza virus infection, although we found that there was considerable variation in results among study sites.
Influenza vaccine effectiveness and statin use among adults in the United States, — [published online October 27, ].
Video: Statins and influenza vaccine What flu vaccine options are available?
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Statin Use Does Not Modify Flu Vaccine Effectiveness in Adults The Cardiology Advisor
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|Statin use did not modify the effect of vaccination on influenza when analyzed by type and subtype.
Risk differences varied from It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Perspective For this study, which was a large, very carefully done observational study, the authors found little, if any, effect of statins on influenza vaccine effectiveness.
We examined whether inclusion of statin use in the model confounded VE estimates.
For the first study.
The Impact of Statin Therapy on InfluenzaVaccine Response
Statin use did not modify the effect of vaccination on influenza in adults ≥45 years. Statin medications taken around the time of influenza vaccination do not appear to affect the risk for influenza in older patients.
Disclosure: Schaffner reports currently serving on a data safety monitoring board for Pfizer and previously serving on a data safety monitoring board for Merck; and recently serving as a consultant for Shionogi, Seqirus and SutroVax.
November 18, Arnold S Monto. The findings and conclusions in this report are those of the authors and do not necessarily represent the official views of the US Centers for Disease Control and Prevention CDC.
‘Reassuring’ evidence shows statin use does not impact flu vaccine effectiveness
Sayre, Pennsylvania. Related articles in Web of Science Google Scholar.
Statins and influenza vaccine
|Although some influenza seasons and study enrollees from that site were included in both studies, the study by McLean et al used a different method for determining statin use in its patient population, was limited to 1 site, and covered a different range of influenza seasons, which may account for the different findings in the 2 studies.
Click here to login. For all influenza virus subtypes, the model included, a priori, age group, sex, study site, season, month of illness onset, diabetes, cardiovascular disease, and chronic pulmonary disease. Influenza vaccine effectiveness against pandemic influenza A H1N1 virus differed by vaccine type during in the United States.
Statins, in addition to their lipid-lowering properties, may also have anti-inflammatory effects. Michael L Jackson.